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Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Journal JoVE
Immunologie et infection
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Journal JoVE Immunologie et infection
Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
DOI:

05:53 min

July 06, 2013

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Chapitres

  • 00:05Titre
  • 01:16Preparation of Viral Suspension
  • 02:14Injection of Neonates
  • 03:25In vivo Imaging
  • 05:00Results: Viral Expression Over Time
  • 05:32Conclusion

Summary

Traduction automatique

Human Cytomegalovirus (HCMV) infection of neonates represents an important cause of mental retardation, yet the molecular events leading to virus-induced pathogenesis are still poorly understood. To investigate the dynamics of brain infection, we adapted whole-animal in vivo imaging to perform time-course analysis of neonates infected with a luciferase-recombinant virus.

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