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A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats
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Sciences du comportement
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Journal JoVE Sciences du comportement
A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats

A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats

DOI:
10.3791/50751-v

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10:35 min

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November 11, 2013

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, ,
1Department of Psychology, Center for Studies in Behavioural Neurobiology/Groupe de Recherche en Neurobiologie Comportementale,Concordia University

Chapitres

  • 00:05Titre
  • 02:00Catheters and Connectors
  • 03:09Intravenous Catheterization
  • 06:22Operant Conditioning Chambers
  • 07:02Heroin Self-administration
  • 09:02Results: Lever Responding in Food-restricted and Sated Rats Under Withdrawal
  • 09:53Conclusion

Summary

Traduction automatique

Traduction automatique

A procedure that allows a demonstration of robust augmentation of drug seeking in food-restricted rats is described. Following heroin self-administration training, rats go through an abstinence period, in a drug-free environment, during which they are mildly food restricted. Drug seeking is then tested in the drug-associated environment.

Tags

Keywords: Heroin SeekingFood RestrictionAbstinenceRelapseDrug CravingIntravenous Self-administrationOperant ConditioningExtinctionAnimal ModelClinical Relevance

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