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A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
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1Research Center on Aging and Department of Physiology and Biophysics,Université de Sherbrooke, 2Sherbrooke Molecular Imaging Center, Étienne-Le Bel Clinical Research Center,Université de Sherbrooke, 3Department of Computer Science,Université de Sherbrooke, 4Department of Nuclear Medicine and Radiobiology,Université de Sherbrooke
Chapitres
- 00:05Titre
- 02:19Brain Anatomy with MRI
- 03:19Dual Tracer PET Acquisitions
- 08:29Quantitative PET Analysis
- 12:56Results: Dual Tracer PET-MRI
- 14:00Conclusion
Small-animal positron emission tomography enables the assessment of the brain's two main energy substrates: glucose and ketones. In the present method, 11C-acetoacetate and 18F-fluorodeoxyglucose are injected sequentially in each animal, and their uptake is measured quantitatively in specific brain regions determined from the magnetic resonance images.
