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Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson’s Disease
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Médecine
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Journal JoVE Médecine
Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson’s Disease

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson’s Disease

DOI:
10.3791/50960-v

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08:09 min

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January 07, 2014

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, , ,
1Center for Health Sciences,SRI International, 2Department of Chemistry and Biochemistry,University of California-Santa Cruz

Chapitres

  • 00:05Titre
  • 01:25MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) Preparation
  • 03:50MPTP Administration
  • 05:59Results: 5-LOX and 12/15-LOX Differentially Impact the Nigrostriatal Dopaminergic Vulnerability
  • 07:40Conclusion

Summary

Traduction automatique

Traduction automatique

Lipoxygenase (LOX) isozymes can generate products that may increase or decrease neuroinflammation and neurodegeneration. A gene-environment interaction study could identify LOX isozyme-specific effects. Using the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of nigrostriatal damage in two LOX isozyme-deficient transgenic lines allows for comparison of the contribution of LOX isozymes on dopaminergic integrity and inflammation.

Tags

Gene-environment InteractionLipoxygenaseParkinson’s DiseaseMPTPNeurodegenerative DisordersNigrostriatal DegenerationDopamineTyrosine HydroxylaseInflammationGFAPIba-1

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