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1Division of Hematology-Oncology, Department of Internal Medicine,University of Cincinnati College of Medicine, 2Division of Human Genetics,University of Cincinnati College of Medicine, 3Department of Radiology,University of Cincinnati College of Medicine, 4Division of Rheumatology, Cincinnati Children’s Hospital Medical Center,University of Cincinnati College of Medicine, 5Solid Tumor Biology Program, James Comprehensive Cancer Center,The Ohio State University Medical Center, 6Department of Neurological Surgery, James Comprehensive Cancer Center,The Ohio State University Medical Center
Chapitres
- 00:05Titre
- 01:25Preparation of Animal Models and Fluorescently-labeled SapC-DOPS Nanovesicles
- 03:27Fluorescence Imaging
- 05:30Results: Optical Imaging of Brain Tumors and Arthritis in SapC-DOPS Nanovesicle Injected Mice
- 08:35Conculsion
Descriviamo un multi-angolo di rotazione imaging ottico del sistema (Maroi) in vivo quantificazione di un marcatore fluorescente consegnato da saposin C (SAPC)-dioleoylphosphatidylserine (DOPS) nanovesicles. Impiegando modelli murini di cancro e artrite, si dimostra come l'analisi della curva Maroi segnale può essere utilizzato per la mappatura precisa e caratterizzazione biologica dei processi patologici.
