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Assessment of Murine Exercise Endurance Without the Use of a Shock Grid: An Alternative to Forced Exercise
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Sciences du comportement
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Journal JoVE Sciences du comportement
Assessment of Murine Exercise Endurance Without the Use of a Shock Grid: An Alternative to Forced Exercise

Assessment of Murine Exercise Endurance Without the Use of a Shock Grid: An Alternative to Forced Exercise

DOI:
10.3791/51846-v

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07:52 min

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August 14, 2014

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, ,
1Research Service,VA Puget Sound Health Care System, 2Seattle Institute for Biomedical and Clinical Research, 3Division of Gerontology and Geriatric Medicine, Department of Medicine,University of Washington, 4Geriatric Research, Education, and Clinical Center,VA Puget Sound Health Care System

Chapitres

  • 00:05Titre
  • 01:11Experimental Preparation and Acclimation of Mice to the Treadmill
  • 02:37Starting the Run-to-Exhaustion Test
  • 03:59Endpoints and Mice that Stop
  • 05:59Results: Exercise Endurance Reflects the Expression of Cytokine IL-15 in C57BL/6 Mice
  • 07:24Conclusion

Summary

Traduction automatique

Traduction automatique

A method to assess exercise endurance in laboratory mice without the use of a shock grid is demonstrated. This method is a humane refinement that can decrease the confounding effects of stress on experimental parameters.

Tags

Keywords: Exercise EnduranceMurine ModelTreadmillShock GridVoluntary RunningBehavioral CuesTime-to-exhaustionStress ReductionExperimental Refinement

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