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Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution
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Ingénierie
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Journal JoVE Ingénierie
Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution

Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution

DOI:
10.3791/51847-v

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09:59 min

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July 04, 2014

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, , , ,
1Optical Sciences Group, MESA+ Institute,University of Twente, 2Institute of Pharmaceutics and Biopharmaceutics,Heinrich-Heine University, 3Division of Pharmaceutical Technology, Faculty of Pharmacy,University of Helsinki

Chapitres

  • 00:05Titre
  • 01:30System Startup and Microscope Setup
  • 02:27System Testing and UV Dissolution Measurement
  • 04:14CARS Dissolution Video and CARS Wavelength Tuning
  • 05:15The Dissolution Experiment
  • 07:01Post Dissolution
  • 07:49Results: CARS Dissolution Video and UV Dissolution Profile
  • 09:28Conclusion

Summary

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Coherent anti-Stokes Raman scattering (CARS) microscopy is combined with an intrinsic flow-through dissolution setup to allow in situ and real-time visualization of the surface of pharmaceutical tablets undergoing dissolution. Using this custom-built setup, it is possible to correlate CARS videos with drug dissolution profiles recorded using inline UV absorption spectroscopy.

Tags

Keywords: Coherent Anti-Stokes Raman Scattering (CARS) MicroscopyPharmaceutical TabletsDissolutionTheophylline AnhydrateEthyl CelluloseTheophylline MonohydrateUV Absorption SpectroscopyDissolution RateSurface CompositionSurface Structure

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