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Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
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Chapitres
- 00:05Titre
- 01:14E. coli K1 Feeding and Disease Severity Assessment
- 03:27Collecting the GI Tract for Downstream Analysis
- 05:44Tissue Processing and Homogenization
- 06:31Results: E. coli K1 Colonization Mimics Natural Infection in Humans
- 08:03Conclusion
Here, a procedure is described for the establishment of systemic infection in the neonatal rat with cultures of Escherichia coli K1. This non-invasive procedure permits colonization of the gastrointestinal tract, translocation of the pathogen to the systemic circulation, and invasion of the central nervous system at the choroid plexus.
