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Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
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Chapitres
- 00:05Titre
- 01:50Handling and Food Restriction
- 02:33Magazine Training
- 03:56Lever Press Training: Pre-training Stage
- 05:19Lever Press Training: Lever Press Training on a Discrete Trial Schedule
- 06:23Signal Attentuation and Regular Extinction
- 07:03Testing
- 07:45Results: Alterations in Signal Attentuation after Drug Intervention
- 08:32Conclusion
The goal of the protocol described in this paper is to induce compulsive-like behavior in rats for the study of obsessive-compulsive disorder (OCD). This behavior is precipitated by attenuating a signal indicating that a lever-press response was effective in producing food.
