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Chapitres
- 00:05Titre
- 01:19Monitoring Transcellular Spreading of Prion-like Proteins by In Vivo Time-lapse Imaging
- 03:31Genome-wide Screen for Suppression of Prion-induced Toxicity in C. elegans
- 06:22Confirmation of Preliminary Screen Hits
- 09:57Results: Analyzing the Spreading and Toxicity of Prion-like Proteins
- 12:29Conclusion
Prion-like propagation of protein aggregates has recently emerged as being implicated in many neurodegenerative diseases. The goal of this protocol is to describe, how to use the nematode C. elegans as a model system to monitor protein spreading and to investigate prion-like phenomena.
