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在肠系膜淋巴管空心​​大鼠模型:应用肠淋巴药物运输的评估
Journal JoVE
Immunologie et infection
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Journal JoVE Immunologie et infection
The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport
DOI:

13:17 min

March 06, 2015

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Chapitres

  • 00:05Titre
  • 02:10Cannulation of the Mesenteric Lymph Duct
  • 05:56Cannulation of the Duodenum and Carotid Artery
  • 10:14Results: Representative Mesenteric Lymph Flow Rate and Lipid and Drug Transport Data
  • 12:22Conclusion

Summary

Traduction automatique

Here we describe a technique to cannulate the mesenteric lymph duct in rats which enables quantification of lipid and drug transport via the lymphatic system following intestinal delivery. The technique can be adapted to assess mesenteric lymph concentrations and/or transport of fluid, immune cells, peptides, proteins and lipophilic molecules.

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