마우스의 담관 결찰 : 폐쇄성 담즙에 의한 염증성 간 손상과 섬유화의 유도

Disruption of bile flow results in severe inflammatory cholestatic liver injury with a characteristic time-dependent sequence of morphological alterations. Here we present a protocol for the surgical ligation of the common bile duct in mice that allows to induce a strong fibrotic response after 21 to 28 days.