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Endokrin ve Ekzokrin yeniden programlanması ve Silahların Yayılmasını Önleme Modeli Olarak Pankreas kanalının bağlanmasını yoluyla Fare Pankreas Cerrahi Sakatlık
Journal JoVE
Médecine
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Journal JoVE Médecine
Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation
DOI:

07:44 min

August 07, 2015

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Chapitres

  • 00:05Titre
  • 01:46Pancreatic Duct Ligation (PDL)
  • 04:08PDL/Sham Pancreas Tail Harvest
  • 05:17Results: PDL Induces Acinar Atrophy and Inflammation without Affecting Bodyweight and Glycemia
  • 07:00Conclusion

Summary

Traduction automatique

This protocol describes an injury model involving the surgical ligation of the pancreatic duct in the adult mouse pancreas, resulting in severe injury that establishes an environment that allows beta cell neogenesis and proliferation. This model can be used as a tool to study mechanisms involved in beta cell formation.

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