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A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning
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Chapitres
- 00:05Titre
- 01:15Stereotaxic Surgery for Viral Infusion
- 04:43Pharmacological Treatment (Administration of the Designer Drug) and Behavioral Procedure (Sensory Preconditioning)
- 07:26Post Procedure Analyses
- 07:54Results: Sensory Preconditioning in Silenced and Control Rats
- 08:53Conclusion
This protocol describes how to temporarily and remotely silence neuronal activity in discrete brain regions while rats are engaged in learning and memory tasks. The approach combines pharmacogenetics (Designer-Receptors-Exclusively-Activated-by-Designer-Drugs) with a behavioral paradigm (sensory preconditioning) that is designed to distinguish between different components of learning.
