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Electrophysiological Motor Unit Number Estimation (MUNE) Measuring Compound Muscle Action Potential (CMAP) in Mouse Hindlimb Muscles
Journal JoVE
Sciences du comportement
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Journal JoVE Sciences du comportement
Electrophysiological Motor Unit Number Estimation (MUNE) Measuring Compound Muscle Action Potential (CMAP) in Mouse Hindlimb Muscles

Electrophysiological Motor Unit Number Estimation (MUNE) Measuring Compound Muscle Action Potential (CMAP) in Mouse Hindlimb Muscles

DOI:
10.3791/52899-v

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09:07 min

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September 25, 2015

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, , , , ,
1Department of Neurology,The Ohio State University Wexner Medical Center, 2Department of Physical Medicine and Rehabilitation,The Ohio State University, 3Department of Neuroscience,The Ohio State University Wexner Medical Center, 4Department of Biochemistry and Pharmacology,The Ohio State University Wexner Medical Center

Chapitres

  • 00:05Titre
  • 02:17Recording Setup and Equipment
  • 03:46Sciatic CMAP
  • 04:44Average Single Motor Unit Potential Size and MUNE Calculation
  • 07:29Results: Example Sciatic CMAP and MUNE
  • 08:21Conclusion

Summary

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We present refined protocols that allow in vivo monitoring of motor unit function in the mouse. Techniques to measure compound muscle action potential (CMAP) and motor unit number estimation (MUNE) in the mouse hind limb muscles innervated by the sciatic nerve are described.

Tags

ElectrophysiologyMotor Unit Number EstimationMUNECompound Muscle Action PotentialCMAPMouse Hindlimb MusclesNeuromuscular SystemSciatic NerveMotor NeuronsMotor Unit PotentialSubmaximal StimuliTranslational Potential

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