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The Mouse Round-window Approach for Ototoxic Agent Delivery
 

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

Article DOI: 10.3791/53131-v • 12:21 min • November 26th, 2015
November 26th, 2015 •
1, 2, 3, 2
1Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, 2Department of Pathology and Laboratory Sciences, Medical University of South Carolina, 3Intuitive Surgical, Inc

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Various methods exist for introducing ototoxic agents to the cochleae of animal models. Presented is a surgical protocol for delivery of ototoxic agents to the round window niche. The procedure is reliable, creates targeted intra-cochlear lesions, and avoids mechanical damage to the microarchitecture. Examination of cochlear self-repair/regeneration is possible.

Tags

Cochlear Cell Degeneration Ototoxic Agent Delivery Round Window Niche Cochlear Injury Auditory Pathophysiology Cochlear Cell Regeneration Animal Model Hearing Loss
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