Journal
/
Médecine
/
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Journal JoVE
Médecine
Un abonnement à JoVE est nécessaire pour voir ce contenu.  Connectez-vous ou commencez votre essai gratuit.
Journal JoVE Médecine
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

DOI:
10.3791/53196-v

•

07:36 min

•

November 20, 2015

•

, , , ,
1Department of Pediatrics,University of New Mexico, 2Department of Neurosciences,University of New Mexico, 3Department of Neurosurgery,Boston Children’s Hospital, 4Department of Neurology,Harvard Medical School

Chapitres

  • 00:05Titre
  • 01:12Abdominal Laparotomy
  • 02:52Aneurysm Clip Placement
  • 04:09Lipopolysaccharide (LPS) Amniotic Sac Injection
  • 05:45Results: Representative Effects of Transient Systemic Hypoxia-ischemia (TSHI) + LPS in Embryonic Rats
  • 07:00Conclusion

Summary

Traduction automatique

Traduction automatique

Encephalopathy of prematurity encompasses the central nervous system abnormalities associated with injury from preterm birth. This report describes a clinically relevant rat model of in utero transient systemic hypoxia-ischemia and intra-amniotic lipopolysaccharide administration (LPS) that mimics chorioamnionitis, and the related impact of infectious stimuli and placental underperfusion on CNS development.

Tags

Keywords: Encephalopathy Of PrematurityPrenatal Hypoxia-ischemiaIntra-amniotic LipopolysaccharideRat ModelCentral Nervous System AbnormalitiesPreterm BirthPlacental UnderperfusionChorioamnionitisInflammationWhite Matter InjuryFunctional Deficits

Article

Embed

AJOUTER À LA PLAYLIST

Usage Statistics

Vidéos Connexes

check_url/fr/53196?article_type=v

Modeling Stroke in Mice – Middle Cerebral Artery Occlusion with the Filament Model
check_url/fr/53196?article_type=v

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
check_url/fr/53196?article_type=v

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
check_url/fr/53196?article_type=v

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy
check_url/fr/53196?article_type=v

Assessing Transmissible Spongiform Encephalopathy Species Barriers with an In Vitro Prion Protein Conversion Assay
check_url/fr/53196?article_type=v

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
check_url/fr/53196?article_type=v

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
check_url/fr/53196?article_type=v

Circumscribed Capsular Infarct Modeling Using a Photothrombotic Technique
check_url/fr/53196?article_type=v

Preparation of Decellularized Kidney Scaffolds in Rats
check_url/fr/53196?article_type=v

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Read Article