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A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS
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Médecine
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Journal JoVE Médecine
A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

DOI:
10.3791/53257-v

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06:49 min

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October 06, 2015

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, , , , ,
1ALS Therapy Development Institute

Chapitres

  • 00:05Titre
  • 01:35Mouse Housing and Weighing
  • 02:09Neurological Test Descriptions
  • 03:11Neurological Scoring System
  • 05:12Results: Evaluating Disease Progression
  • 06:18Conclusion

Summary

Traduction automatique

Traduction automatique

This video protocol describes a sensitive, reliable, and quick method for evaluating the neuromuscular deficits in a transgenic mouse model of amyotrophic lateral sclerosis.

Tags

Keywords: ALSSOD1-G93AMouse ModelNeurological Scoring SystemNeuroScorePhenotypic ScreeningHindlimb FunctionDisease ProgressionParalysisVideo Protocol

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