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Diffuse optisk spektroskopi for kvantitativ vurdering av akutt Ioniserende stråling Induced Skin Toxicity bruke en mus modell
Journal JoVE
Médecine
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Journal JoVE Médecine
Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model

Diffuse optisk spektroskopi for kvantitativ vurdering av akutt Ioniserende stråling Induced Skin Toxicity bruke en mus modell

DOI:
10.3791/53573-v

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06:21 min

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May 27, 2016

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, , , , , ,
1Department of Radiation Oncology,University of Toronto, 2Department of Physics,Ryerson University, 3Department of Medical Biophysics,University of Toronto, 4Ontario Cancer Institute / Campbell Family Institute for Cancer Research

Chapitres

  • 00:05Titre
  • 00:46Diffuse Optical Spectroscopy (DOS) Data Acquisition: Preparations
  • 01:55Taking DOS Measurements from an Anesthetized Mouse
  • 03:01Mouse Irradiation
  • 04:32Results: DOS and Traditional Measurements
  • 05:36Conclusion

Summary

Traduction automatique

Traduction automatique

We present a diffuse optical spectroscopic (DOS) approach that provides quantitative optical biomarkers of skin response to radiation. We describe DOS instrumentation design, optical parameters extraction algorithms and the animal handling procedures required to yield representative data from a pre-clinical mouse model of radiation induced erythema.

Tags

Keywords: Diffuse Optical SpectroscopyAcute Ionizing RadiationSkin ToxicityMouse ModelBiomarkerRadiation TherapyRadiation Skin ToxicityReflectanceAnesthesiaMouse Irradiation

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