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Bio-ingénierie
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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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Bio-ingénierie
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Journal JoVE Bio-ingénierie
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

DOI:
10.3791/53603-v

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08:13 min

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February 16, 2016

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, , , ,
1Department of Genetics,Erasmus MC, Rotterdam, 2Department of Experimental Cardiology,Erasmus MC, Rotterdam, 3PerkinElmer, Inc., 4Department of Vascular Surgery,Erasmus MC, Rotterdam, 5Department of Radiation Oncology,Erasmus MC, Rotterdam

Chapitres

  • 00:05Titre
  • 01:09Cardiac Ischemic Model Preparation
  • 02:38Micro Computer Tomography (MicroCT) Imaging
  • 05:45Results: Representative MicroCT and Myocardial Perfusion Imaging
  • 07:03Conclusion

Summary

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This method outlines the use of Quantum Micro-Computed Tomography (MicroCT) to assess cardiac morphology, function, perfusion, metabolism and viability with iodinated contrast agent in mice with experimentally-induced myocardial ischemia. The technique can be applied for non-destructive high-throughput longitudinal in vivo imaging of various animal models of human heart disease.

Tags

Keywords: Cardiac Micro-computed TomographyMyocardial StructureMyocardial FunctionMyocardial PerfusionMyocardial ViabilityCardiac IschemiaCardiac PathophysiologyCardiac Disease DevelopmentCardiac ParametersNon-invasive EvaluationPreclinical ToolMouse ModelLeft Coronary Artery LigationInfarct InductionMicroCT Imaging

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