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אינדוקציה של הפעלה האימהית חיסונית בעכברים בשלב אמצע הריון עם ויראלי לחקות פולי (אני: C)
Journal JoVE
Immunologie et infection
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Journal JoVE Immunologie et infection
Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)
DOI:

07:13 min

March 25, 2016

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Chapitres

  • 00:05Titre
  • 00:57Timed-mating Pair Setup
  • 02:23Poly(I:C) Injection
  • 03:55MIA Adult Offsrping Behavioral Abnormality Evaluation
  • 05:33Results: MIA Adult Offsrping Exhibit Abnormalities Associated with Autism and Schizophrenia
  • 06:42Conclusion

Summary

Traduction automatique

Maternal immune activation (MIA) is a model for an environmental risk factor of autism and schizophrenia. The goal of this article is to provide a step-by-step procedure of how to induce MIA in the pregnant mice in order to enhance the reproducibility of this model.

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