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Bioengineering

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JoVE Journal Bioengineering
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
 

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Article DOI: 10.3791/53680-v • 09:11 min • February 13th, 2016
February 13th, 2016 •
*1,2, *1, *1, 1, 2,3, 1
1Department of Biological Sciences, Kent State University, 2Liquid Crystal Institute, Kent State University, 3Chemical Physics Interdisciplinary Program, Kent State University
* These authors contributed equally

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We present a facile method to fabricate a biodegradable gelatin-based drug release platform that is magneto-thermally responsive. This was achieved by incorporating superparamagnetic iron oxide nanoparticles and poly(N-isopropylacrylamide-co-acrylamide) within a spherical gelatin micro-network crosslinked by genipin, in conjunction with an alternating magnetic field application system.

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Alternating Magnetic Field Hybrid Gelatin Microgels Controlled Drug Release Magnetothermally Responsive Nanoparticle Microgel Hybrids Facile Method Proof Of Simple Process Magnetic Nanoparticles Thermoresponsive PNIPAM Copolymers Gelatin Matrix Drug Release Alternating Magnetic Field Induction Swelling Of PNIPAM Copolymer Increasing Temperature Of Nanoparticles Magnetic Waves On-Demand Drug Delivery System Non-invasive External Stimuli
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