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Protocol voor de synthese van<em> Ortho</em> -trifluoromethoxylated anilinederivaten
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Journal JoVE Chimie
Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
DOI:

08:43 min

January 19, 2016

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Chapitres

  • 00:05Titre
  • 00:53Precursor Preparation: Synthesis of Methyl 4-(N-hydroxyacetamido) Benzoate
  • 04:33Synthesis of Methyl 4-(N-trifluoromethoxy)acetamido) Benzoate
  • 05:58Synthesis of Methyl 4-Acetamido-3-(trifluoromethoxy) Benzoate via Trifluoromethoxy-migration
  • 07:14Results: Synthesis of Trifluoromethoxylated Aniline Derivatives Using Togni Reagent II
  • 08:12Conclusion

Summary

Traduction automatique

An operationally simple procedure for the synthesis of ortho-trifluoromethoxylated aniline derivatives via a two-step sequence of O-trifluoromethylation of N-aryl-N-hydroxyacetamide followed by thermally induced intramolecular OCF3-migration is reported.

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