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Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
Journal JoVE
Médecine
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Journal JoVE Médecine
Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
DOI:

15:04 min

May 20, 2016

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Chapitres

  • 00:05Titre
  • 01:06Image-Based Nasal Airway Preparation
  • 04:32Passive Control of Particles: Intubation
  • 07:37Active Control of Particles: Magnetophoretic Guidance
  • 09:57Testing of 2D/3D Nose Models
  • 12:57Results: Alternative Nasal Devices Through Intubation and Magnetophoretic Guidance Prove Superior to Conventional Methods
  • 14:01Conclusion

Summary

Traduction automatique

This manuscript reviews the modeling and simulations of different protocols to deliver medications to the olfactory region in image-based nasal airway models. Multiple software modules are used to develop the anatomically accurate nose model, generate computational mesh, simulate nasal airflows, and predict particle deposition at the olfactory region.

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