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Análisis alta Content Screening para evaluar los efectos toxicológicos de nocivo Componentes y potencialmente perjudicial (HPHC)
Journal JoVE
Biologie
This content is Free Access.
Journal JoVE Biologie
High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
DOI:

11:38 min

May 10, 2016

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Chapitres

  • 00:05Titre
  • 01:03Real Time Cell Analyzer (RTCA)-based Dose Range Finding (DRF)
  • 04:26Preparation for Measuring Toxicological Effects by High-content Screening (HCS)
  • 06:27Cytotoxicity Assay
  • 09:19Results: Representative Results for 1-Aminonaphtalene
  • 10:26Conclusion

Summary

Traduction automatique

The objective of the study was to assess the biological impact of 15 cigarette smoke constituents using a combination of an impedance-based real time cell analyzer and a high-content screening (HCS)-based platform for toxicological assessment in vitro. This study provides information on effective doses, toxicity and modes of action of the tested compounds.

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