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Journal JoVE
Médecine
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Journal JoVE Médecine
Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells
DOI:

11:44 min

August 29, 2016

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Chapitres

  • 00:05Titre
  • 00:59Generation of Acute Liver Injury Mouse Model
  • 02:52Preparation of Human Hepatic Stem Cells
  • 04:41Intrasplenic Transplantation of Human Hepatic Stem Cells
  • 06:25Detection of Transplanted Human Hepatic Stem Cell-derived Hepatocytes in the Mouse Liver
  • 08:13Results: Humanization of Mouse Livers using Human Hepatic Stem Cells
  • 10:09Conclusion

Summary

Traduction automatique

Here, we present a novel humanized mouse liver model generated in Alb-toxin receptor mediated cell knockout (TRECK)/SCID mice following the transplantation of immature and expandable human hepatic stem cells.

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