Генетические и биохимические подходы к<em> В Vivo</em> и<em> In Vitro</em> Оценка белка олигомеризации: The Рианодин Рецептор Case Study

Oligomerization of the ryanodine receptor, a homo-tetrameric ion channel mediating Ca²⁺ release from intracellular stores, is critical for skeletal and cardiac muscle contraction. Here, we present complementary in vivo and in vitro methods to detect protein self-association and determine homo-oligomer stoichiometry.