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Investigations on the Ga(III) Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue
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Investigations on the Ga(III) Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue

Investigations on the Ga(III) Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue

DOI:
10.3791/54334-v

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11:22 min

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August 17, 2016

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, , ,
1Clinic of Nuclear Medicine,University Hospital Jena, 2Friedrich Schiller University

Chapitres

  • 00:05Titre
  • 00:37Preparation of EOB-DTPA and Ga[EOB-DTPA]
  • 03:28General Labeling Procedure
  • 05:03In Vitro Stability
  • 07:55Determination of Distribution Coefficient LogD
  • 08:59Results: Analysis and Characterization of EOB-DTPA and Its Ga(III) and 68Ga Complexes
  • 10:32Conclusion

Summary

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A procedure for the isolation of EOB-DTPA and subsequent complexation with natural Ga(III) and 68Ga is presented herein, as well as a thorough analysis of all compounds and investigations on labeling efficiency, in vitro stability and the n-octanol/water distribution coefficient of the radiolabeled complex.

Tags

Keywords: Ga(III) ComplexEOB-DTPA68Ga RadiolabelingGallium-68 Tracer ChemistryLabeling ConditionsTracer StabilityLipophilicityGadoxetic AcidOxalic AcidHydrochloric AcidSodium HydroxideGallium TrichlorideAmmoniaAmmonium ChloridePSH Plus CartridgeSilica Column Generator

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