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Intravascular Delivery of Biologics to the Rat Kidney
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Médecine
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Journal JoVE Médecine
Intravascular Delivery of Biologics to the Rat Kidney

Intravascular Delivery of Biologics to the Rat Kidney

DOI:
10.3791/54418-v

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07:29 min

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September 01, 2016

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, , , ,
1Divisions of Cardiovascular Diseases, Department of Internal Medicine,Mayo Clinic, 2Divisions of Nephrology and Hypertension, Department of Internal Medicine,Mayo Clinic

Chapitres

  • 00:05Titre
  • 00:57Surgical Preparation
  • 01:57Surgical Procedure
  • 05:36Results: Intravascular Delivery of Rat Recombinant VEGF into the Rat Kidney
  • 06:41Conclusion

Summary

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The administration of drugs for recovery of kidney function requires control of the localization and distribution of the therapeutic compound. Here, we describe in detail a simple technique for intrarenal delivery of drugs in rats. This procedure may be easily performed with no mortality and high reproducibility.

Tags

Intravascular DeliveryBiologicsRat KidneyRenal ArteryLocalized Therapeutic EffectRenal Microvascular CompartmentRenal PathologiesRenal Microvascular FunctionKidney DiseasesKidney DamageSurgeryAnesthesiaLaparotomyAortaRenal ArteryMicrovascular ClipsIntravenous Catheter

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