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A Síntese de hidrogéis RGD-funcionalizado como uma ferramenta para aplicações terapêuticas
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Chapitres
- 00:05Titre
- 01:08Synthesis of Arginylglycylaspartic Acid (RGD)-azide Derivative and Polyacrylic Acid (PAA) Alkyne Modification
- 04:00Synthesis of PAA-RGD Polymer
- 05:37RGD-functionalized Hydrogel Synthesis
- 07:28Results: Hydrogel Synthesis and Characterization
- 08:54Conclusion
We present a protocol for the synthesis of RGD-functionalized hydrogels as devices for cell and drug delivery. The procedure involves copper catalyzed alkyne-azide cycloaddition (CuAAC) between alkyne-modified polyacrylic acid (PAA) and a RGD-azide derivative. The hydrogels are formed using microwave-assisted polycondensation and their physicochemical properties are investigated.
