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Chapitres
- 00:05Titre
- 01:09Synthesis of a Linear Peptoid
- 05:08Side-chain Deprotection and Cleavage from Resin
- 06:32Cytotoxicity Assay against Leishmania mexicana Axenic Amastigotes
- 09:12Results: Synthesis and Characterization of Peptoids and Their Cytotoxicity to Leishmania mexicana
- 10:33Conclusion
A protocol to synthesize peptoids with mixed cationic functionality in the same sequence is presented (lysine- and arginine-type monomers). Subsequent testing of these compounds against Leishmania mexicana, the protozoan parasites that cause cutaneous leishmaniasis, is also described.
