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Drug nyorientering Hypotese Generation Brug af "RE: fine Drugs" System
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Médecine
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Journal JoVE Médecine
Drug Repurposing Hypothesis Generation Using the “RE:fine Drugs” System

Drug nyorientering Hypotese Generation Brug af "RE: fine Drugs" System

DOI:
10.3791/54948-v

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05:10 min

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December 11, 2016

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, , ,
1Department of Biomedical Informatics,The Ohio State University, 2Research Information Solutions and Innovation,The Research Institute at Nationwide Children’s Hospital

Chapitres

  • 00:05Titre
  • 00:41Initiation of Queries from Gene, Drug, or Disease Terms
  • 01:44Exploration of Advanced Options
  • 03:23Results: “RE:fine Drugs” System Output Using the IL2RB Gene as an Example
  • 04:45Conclusion

Summary

Traduction automatique

Traduction automatique

Here we describe a protocol using the web-based drug repurposing hypothesis generation tool: "RE:fine Drugs." This protocol can be modified to a user's preferences at the level of the query type (gene, drug or disease) and/or the range of available advanced options.

Tags

Keywords: Drug RepurposingHypothesis GenerationRE:fine DrugsGenome-wide Association StudyPhenome-wide Association StudyDrug DiscoveryDisease IndicationsGeneDrugAdvanced SearchP-valueEffect SizeStudy TypeDrugBankMedlineClinicalTrials.govRepurposing Potential

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