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Immunology and Infection

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JoVE Journal Immunology and Infection
In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging
 

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging

Article DOI: 10.3791/54997-v • 09:29 min • April 28th, 2017
April 28th, 2017 •
1,2,3, 1, 1, 4, 1, 1
1Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, 2Department of Medical Oncology, Beijing Institute of Translational Medicine, Chinese Academy of Sciences, 3Cancer Center, Aviation General Hospital, Beijing, 4Infectious Disease Service, Brooke Army Medical Center

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Infections caused by multidrug-resistant (MDR) bacterial strains have emerged as a serious threat to public health, necessitating the development of alternative therapeutics. We present a protocol to evaluate the effectiveness of antimicrobial blue light (aBL) therapy for MDR Acinetobacter baumannii infections in mouse burns by using bioluminescence imaging.

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Keywords: Antimicrobial Blue Light Therapy Multidrug-resistant Acinetobacter Baumannii Burn Infections Bioluminescence Imaging Non-antibiotic Approach Localized Bacterial Infections Thermal Injury Bacterial Suspension CFU PBS
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