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El uso de modelos de pez cebra de Infecciones por Virus de la Influenza Humana A a la pantalla medicamentos antivirales y caracterizar inmune del huésped respuestas de las células
Journal JoVE
Immunologie et infection
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Journal JoVE Immunologie et infection
Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses
DOI:

09:07 min

January 20, 2017

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Chapitres

  • 00:05Titre
  • 00:44Systemic Influenza A Virus Infection at 48 Hr Post Fertilization
  • 03:07Localized, Swim Bladder IAV Infection of Tg(mpx:mCherry) Transgenic Zebrafish
  • 04:19Anti-viral Drug Treatment
  • 05:23Mounting Zebrafish for Imaging
  • 06:39Results: Anti-viral Drug Treatment of IAV Infection in Zebrafish
  • 08:25Conclusion

Summary

Traduction automatique

Systemic and localized zebrafish infection models for human influenza A virus are demonstrated. Using a systemic infection model, zebrafish can be used to screen antiviral drugs. Using a localized infection model, zebrafish can be used to characterize host immune cell responses.

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