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The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
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Chapitres
- 00:00Titre
- 01:02Neonatal Alcohol Exposure
- 02:53Eyelid Surgery
- 02:56Eyelid Surgery: Materials and Setup
- 03:13Eyelid Surgery: Animal Preparation
- 03:50Eyelid Surgery: Surgery
- 09:34Trace Eyeblink Classical Conditioning
- 09:37Trace Eyeblink Classical Conditioning: Animal Preparation and System Setup
- 10:40Trace Eyeblink Classical Conditioning: Animal Status Check
- 11:08Trace Eyeblink Classical Conditioning: Explantation of Trace ECC Procedure
- 15:00Trace Eyeblink Classical Conditioning: Software Setup and Begin Testing
- 15:44Trace Eyeblink Classical Conditioning: Live Recording: Unintubated-control Rat Session 1 Trial 15
- 15:57Trace Eyeblink Classical Conditioning: Replay at 0.30x Speed
- 16:14Trace Eyeblink Classical Conditioning: Progression of Training Through Six Sessions
- 16:36Trace Eyeblink Classical Conditioning: Development of Adaptive CRs
- 16:46Trace Eyeblink Classical Conditioning: Live Recording: Unintubated-control Rat Session 6 Trial 96
- 16:58Trace Eyeblink Classical Conditioning: Replay at 0.30x Speed
- 17:18Trace Eyeblink Classical Conditioning: Live Recording: Alcohol-intubated-control Rat Session 6 Trial 100
- 17:35Representative Results
- 19:00Conclusion
Trace eyeblink classical conditioning (ECC) was used to assess hippocampal-dependent associative learning in adult rats that were administered a high concentration (11.9% v/v) of alcohol during early neonatal brain development. In general, ECC procedures are sound diagnostic tools for detecting brain dysfunction across many psychological and biomedical settings.
