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使用的跟踪经典条件反射，评估胎儿酒精谱系障碍大鼠模型海马功能障碍
Journal JoVE
Neurosciences
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Journal JoVE Neurosciences
The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
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使用的跟踪经典条件反射，评估胎儿酒精谱系障碍大鼠模型海马功能障碍

DOI:
10.3791/55350-v

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19:57 min

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August 05, 2017

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, , , , ,
1Department of Psychology,East Carolina University, 2Multidisciplinary Studies Program in Neuroscience,East Carolina University

Chapitres

  • 00:00Titre
  • 01:02Neonatal Alcohol Exposure
  • 02:53Eyelid Surgery
  • 02:56Eyelid Surgery: Materials and Setup
  • 03:13Eyelid Surgery: Animal Preparation
  • 03:50Eyelid Surgery: Surgery
  • 09:34Trace Eyeblink Classical Conditioning
  • 09:37Trace Eyeblink Classical Conditioning: Animal Preparation and System Setup
  • 10:40Trace Eyeblink Classical Conditioning: Animal Status Check
  • 11:08Trace Eyeblink Classical Conditioning: Explantation of Trace ECC Procedure
  • 15:00Trace Eyeblink Classical Conditioning: Software Setup and Begin Testing
  • 15:44Trace Eyeblink Classical Conditioning: Live Recording: Unintubated-control Rat Session 1 Trial 15
  • 15:57Trace Eyeblink Classical Conditioning: Replay at 0.30x Speed
  • 16:14Trace Eyeblink Classical Conditioning: Progression of Training Through Six Sessions
  • 16:36Trace Eyeblink Classical Conditioning: Development of Adaptive CRs
  • 16:46Trace Eyeblink Classical Conditioning: Live Recording: Unintubated-control Rat Session 6 Trial 96
  • 16:58Trace Eyeblink Classical Conditioning: Replay at 0.30x Speed
  • 17:18Trace Eyeblink Classical Conditioning: Live Recording: Alcohol-intubated-control Rat Session 6 Trial 100
  • 17:35Representative Results
  • 19:00Conclusion

Summary

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Traduction automatique

痕量经典条件反射 (ECC) 用于评估了的成年大鼠海马依赖联想学习管理高 (11.9 %v / v) 乙醇浓度早期新生儿大脑发育。ECC 程序一般声音诊断工具检测脑功能障碍跨越心理和生物医学的许多设置。

Tags

Keywords: Trace Eyeblink Classical ConditioningHippocampal DysfunctionFetal Alcohol Spectrum DisordersNeonatal Rat PupsAlcohol ExposureThird TrimesterHippocampusAssociative LearningBinge Exposure ParadigmAlcohol SolutionPE-10 TubeEsophagusGastroesophageal Sphincter

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