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Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
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Médecine
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Journal JoVE Médecine
Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

DOI:
10.3791/55356-v

•

04:22 min

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March 30, 2017

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, , , , ,
1RTI International, 2Oklahoma University Health Science Center, 3University of North Carolina at Chapel Hill

Chapitres

  • 00:05Titre
  • 00:55Dosator Assembly, Filling and Actuation
  • 02:39Results: Representative Pharmacokinetic Evaluation via Passive Inhalation
  • 03:38Conclusion

Summary

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Traduction automatique

During development of drugs for pulmonary delivery, it is necessary to evaluate pharmacokinetics and efficacy in an animal model. We present a method to build a disposable aerosol dispersion system from of-the-shelf components that can be used to administer intrapulmonary dry powder aerosol to rodents.

Tags

Disposable DosatorPulmonary InsufflationTherapeutic AgentsSmall AnimalsDry Powder AerosolAerosol Dispersion SystemAerosol SciencePharmacokineticsEfficacy TestingPolypropylene Microcentrifuge TubeStainless Steel Wire ClothAnalytical MicrobalanceSyringeDosing PortExposure ChamberAcrylic Dosing Chamber

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