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Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening
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Chapitres
- 00:05Titre
- 01:05Engineering Heart Tissue (EHT) Generation
- 03:40Contraction Analysis
- 05:48Drug Screening
- 08:20Results: Representative EHT Contraction Analysis
- 09:32Conclusion
Here, we show the generation of human engineered heart tissue from induced pluripotent stem cells (hiPSC)-derived cardiomyocytes. We present a method to analyze contraction force and exemplary alteration of contraction pattern by the hERG channel inhibitor E-4031. This method shows high level of robustness and suitability for cardiac drug screening.
