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のフェーズI代謝コンピテンシーを特徴づけるために質量分析とルミネベースのアプローチ<em>インビトロ</em>細胞培養
Journal JoVE
Biochimie
This content is Free Access.
Journal JoVE Biochimie
Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
DOI:

10:44 min

March 28, 2017

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Chapitres

  • 00:05Titre
  • 00:48Cell Culture
  • 02:49CYP Activity Quantification in Cell Cultures: Metabolic Probes, Inducers, and Inhibitors
  • 04:30CYP Activity Quantification in Cell Cultures: Medium Treatment
  • 05:40CYP Activity Quantification in Cell Cultures: Mass Spectrometry (MS)-based Quantification
  • 06:49CYP Activity Quantification in Cell Cultures: Probes Using Luminescence-based Methods
  • 08:10Results: Quantification of Metabolites Produced by tha Activity of CYP Enzymes Following Cell Incubation with CYP Inducers, Substrates, and Inhibitors
  • 09:35Conclusion

Summary

Traduction automatique

in vitro系の代謝能力は、薬物や毒物の生体内変化及び処分のための重要な要件です。このプロトコルでは、我々は、私は細胞培養で代謝相を評価するための基準の代謝プローブのアプリケーションを記述します。

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