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Uncontrolled Hemorrhagic Shock Modeled via Liver Laceration in Mice with Real Time Hemodynamic Monitoring
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Médecine
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Journal JoVE Médecine
Uncontrolled Hemorrhagic Shock Modeled via Liver Laceration in Mice with Real Time Hemodynamic Monitoring

Uncontrolled Hemorrhagic Shock Modeled via Liver Laceration in Mice with Real Time Hemodynamic Monitoring

DOI:
10.3791/55554-v

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06:11 min

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May 21, 2017

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, , , , ,
1Department of Surgery,University of Pittsburgh, 2Department of Biomedical Engineering,Case Western Reserve University

Chapitres

  • 00:05Titre
  • 00:47Catheter Placement
  • 02:34Liver Laceration
  • 03:42Results: Representative Liver Laceration Analyses
  • 05:04Conclusion

Summary

Traduction automatique

Traduction automatique

Uncontrolled hemorrhage, an important cause of mortality among trauma patients, can be modeled using a standard liver laceration in a murine model. This model results in consistent blood loss, survival, and allows for testing hemostatic agents. This article provides the step-by-step process to perform this valuable model.

Tags

Uncontrolled HemorrhageHemorrhagic ShockResuscitationHemostatic DrugsMolecular MechanismsLiver LacerationMurine ModelReal-time Hemodynamic MonitoringFemoral Artery CatheterizationLaparotomyBlood Pressure

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