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Eksperimentelle modeller til undersøgelse af neuroprotektion af sur postkonditionering mod cerebral iskæmi
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Neurosciences
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Journal JoVE Neurosciences
Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Eksperimentelle modeller til undersøgelse af neuroprotektion af sur postkonditionering mod cerebral iskæmi

DOI:
10.3791/55931-v

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10:13 min

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July 31, 2017

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, , , , , ,
1Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Department of Pharmacology, Key Laboratory of Medical Neurobiology of The Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology,Zhejiang University

Chapitres

  • 00:05Titre
  • 00:57Cortical Slice Preparation
  • 02:43Oxygen-glucose Deprivation and Acidic Postconditioning
  • 04:03Determination of Slice Viability
  • 05:04Middle Cerebral Artery Occlusion
  • 07:22Reperfusion and Acidic Postconditioning
  • 08:16Results: Acidic Preconditioning Protects Against Reperfusion Injury
  • 09:32Conclusion

Summary

Traduction automatique

Traduction automatique

Acid postkonditionering beskytter mod cerebral iskæmi. Her præsenterer vi to modeller til at udføre APC. De opnås henholdsvis ved at overføre kortikostriatale skiver til sur buffer efter oxygen-glucose-deprivation in vitro og ved at inhalere 20% CO 2 efter midter cerebral arterieeklusion i vivo .

Tags

Keywords: NeuroprotectionAcidic PostconditioningCerebral IschemiaCortico Striatal Slice ModelMiddle Cerebral Artery Occlusion ModelIschemic Brain InjuryStroke TherapyAcidosis PostconditioningBrain Slice PreparationGlucose-free ACSFAcidic ACSFSynaptic Function Recovery

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