Journal
/
Médecine
/
Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy
Journal JoVE
Médecine
Un abonnement à JoVE est nécessaire pour voir ce contenu.  Connectez-vous ou commencez votre essai gratuit.
Journal JoVE Médecine
Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy

DOI:
10.3791/56231-v

•

08:34 min

•

September 25, 2017

•

, , , ,
1Institute of Veterinary Physiology and Zurich Center for Integrative Human Physiology (ZIHP),University of Zurich, 2Laboratoire d’Innovation Thérapeutique, UMR7200,Université de Strasbourg – CNRS, 3Department of Cardiology,Canton Hospital Lucerne

Chapitres

  • 00:05Titre
  • 01:03Surgery
  • 05:48Results: Representative Transverse Aortic Constriction (TAC) Validation and Analysis
  • 07:07Conclusion

Summary

Traduction automatique

Traduction automatique

The aim of this protocol is to describe step-by-step the technique of minimally invasive transverse aortic constriction (TAC) in mice. By elimination of intubation and ventilation which are mandatory for the commonly used standard procedure, minimally invasive TAC simplifies the operative procedure and reduces the strain put on the animal.

Tags

Keywords: Minimally InvasiveTransverse Aortic ConstrictionLeft Ventricular HypertrophyMouse ModelSurgical TechniqueAortic ArchPartial SternotomyBlunt DissectionMicrosurgical ForcepsStay SuturesAnesthesiaPostoperative Surveillance

Article

Embed

AJOUTER À LA PLAYLIST

Usage Statistics

Vidéos Connexes

check_url/fr/56231?article_type=v

Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model
check_url/fr/56231?article_type=v

Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging
check_url/fr/56231?article_type=v

Minimally Invasive Transverse Aortic Constriction in Mice
check_url/fr/56231?article_type=v

A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions
check_url/fr/56231?article_type=v

A Closed-chest Model to Induce Transverse Aortic Constriction in Mice
check_url/fr/56231?article_type=v

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
check_url/fr/56231?article_type=v

Invasive Hemodynamic Assessment for the Right Ventricular System and Hypoxia-Induced Pulmonary Arterial Hypertension in Mice
check_url/fr/56231?article_type=v

A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery
check_url/fr/56231?article_type=v

Operating Transverse Aortic Constriction with Absorbable Suture to Obtain Transient Myocardial Hypertrophy
check_url/fr/56231?article_type=v

Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice

Read Article