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Genetics

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JoVE Journal Genetics
Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation
 

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Article DOI: 10.3791/56245-v • 10:33 min • September 4th, 2017
September 4th, 2017 •
*1, *1, 1,2, 1,3
1CytoGnomix Inc., 2Department of Pathology and Laboratory Medicine, Western University, 3Department of Biochemistry, Western University
* These authors contributed equally

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The cytogenetic dicentric chromosome (DC) assay quantifies exposure to ionizing radiation. The Automated Dicentric Chromosome Identifier and Dose Estimator software accurately and rapidly estimates biological dose from DCs in metaphase cells. It distinguishes monocentric chromosomes and other objects from DCs, and estimates biological radiation dose from the frequency of DCs.

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Expedited Radiation Biodosimetry Automated Dicentric Chromosome Identification (ADCI) Dose Estimation Software-based Protocol Machine Learning-based Image Processing Image Filtering Calibration Curve Generation Dicentric Chromosome Detection Radiation Dose Estimation Time-consuming Labor-intensive Tasks Radiation Cytogenic Biodosimetry Chromosomal Images Diagnostic Analyses Genetic Diseases Chromosome Image Analysis Methods Fluorescence Scoring Hybridization Images Testing Multiple Exposed Individuals
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