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Biochemistry

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JoVE Journal Biochemistry
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
 

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Article DOI: 10.3791/56278-v • 08:07 min • September 6th, 2017
September 6th, 2017 •
1, 1, 1, 3, 2, 1
1Division of Nephrology and Hypertension, and the Center for Kidney Research and Therapeutics at the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 2Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, 3School of Biological Sciences and Medical Engineering, Southeast University

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Mismatches in human leukocyte antigen (HLA) sequences between organ donor and recipient pairs are the major cause of antibody-mediated rejection in organ transplantation. Here we present the use of custom antigen arrays that are based on individual donors' HLA sequences to probe anti-donor HLA alloantibodies in organ recipients.

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Keywords: HLA Alloantibodies Organ Transplantation Personalized Peptide Arrays HLA Epitopes Transplant Rejection International Immunogenetics Project FASTA Format Cluster Omega Donor-specific Mismatches 15 Amino Acid Sequences Peptide Array Synthesis
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