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Pentylenetetrazole-Induced Kindling Mouse Model
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Journal JoVE Neurosciences
Pentylenetetrazole-Induced Kindling Mouse Model

Pentylenetetrazole-Induced Kindling Mouse Model

DOI:
10.3791/56573-v

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07:06 min

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June 12, 2018

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,
1Synaptic Plasticity Project,Tokyo Metropolitan Institute of Medical Science

Chapitres

  • 00:04Titre
  • 00:38Injection of PTZ
  • 01:20Three Chamber Test
  • 04:18Contextual Fear Discrimination
  • 05:29Results: Repetitive Injection of PTZ Induces an Increase in Seizure Severity
  • 06:26Conclusion

Summary

Traduction automatique

Traduction automatique

This protocol describes a method of chemical kindling with pentylenetetrazole and provides a mouse model of epilepsy. This protocol can also be used to investigate vulnerability to seizure induction and pathogenesis after epileptic seizures in mice.

Tags

Pentylenetetrazole-Induced KindlingMouse ModelEpilepsySeizureHistological ChangesNeuropsychiatric DisordersPTZSodium ChlorideIntraperitoneal Injection129 SV MiceThree-Chamber ApparatusHabituationSocial InteractionBehavioral Parameters

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