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Pentylenetetrazole-induceret Kindling musemodel
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Journal JoVE Neurosciences
Pentylenetetrazole-Induced Kindling Mouse Model

Pentylenetetrazole-induceret Kindling musemodel

DOI:
10.3791/56573-v

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07:06 min

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June 12, 2018

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,
1Synaptic Plasticity Project,Tokyo Metropolitan Institute of Medical Science

Chapitres

  • 00:04Titre
  • 00:38Injection of PTZ
  • 01:20Three Chamber Test
  • 04:18Contextual Fear Discrimination
  • 05:29Results: Repetitive Injection of PTZ Induces an Increase in Seizure Severity
  • 06:26Conclusion

Summary

Traduction automatique

Traduction automatique

Denne protokol beskriver en metode til kemisk kindling med pentylenetetrazole og giver en musemodel af epilepsi. Denne protokol kan også bruges til at undersøge sårbarhed over for beslaglæggelse induktion og patogenese efter epileptiske anfald hos mus.

Tags

Keywords: Pentylenetetrazole-Induced KindlingMouse ModelEpilepsySeizureHistological ChangesNeuropsychiatric DisordersPTZSodium ChlorideIntraperitoneal Injection129 SV MiceThree-Chamber ApparatusHabituationSocial InteractionBehavioral Parameters

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