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Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
Journal JoVE
Médecine
This content is Free Access.
Journal JoVE Médecine
Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
DOI:

07:56 min

January 26, 2018

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Chapitres

  • 00:05Titre
  • 00:49Tissue Preparation and Strip Dissection
  • 03:00Tissue Mounting
  • 04:06Myometrial Contraction Analysis
  • 05:28Results: Representative Effects and Receptor Selectivity of a Novel Compound in Human Myometrial Contraction
  • 06:41Conclusion

Summary

Traduction automatique

This article describes experimental protocols to study ex vivo contractions of human myometrium and their application in drug discovery. This technique is used to improve the understanding of myometrial physiology and pathophysiology as well as to validate pharmacological data from novel research probes or drug leads.

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