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Metodologi for biomimetiske kemiske Neuromodulationsbehandling af rotte nethinder med neurotransmitteren glutamat In Vitro
Journal JoVE
Bio-ingénierie
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Journal JoVE Bio-ingénierie
Methodology for Biomimetic Chemical Neuromodulation of Rat Retinas with the Neurotransmitter Glutamate In Vitro
DOI:

12:56 min

December 19, 2017

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Chapitres

  • 00:05Titre
  • 01:16Wholemount Retinal Preparation
  • 03:12MEA and Data Acquisition Setup
  • 05:23Glutamate Stimulation Preparation
  • 08:38Retinal Recording and Stimulus Program
  • 10:30Results: Electrode Recordings of Neuronal Activity During Visual, Spontaneous, and Glutamate Injection Recordings
  • 12:06Conclusion

Summary

Traduction automatique

Denne protokol beskriver en roman metode for at undersøge en form for kemisk neurostimulation wholemount rotte nethinder i vitro med neurotransmitteren glutamat. Kemiske neurostimulation er en lovende alternativ til den konventionelle elektrisk neurostimulation retinal neuroner til behandling af uoprettelige blindhed forårsaget af fotoreceptor degenerative sygdomme.

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