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Bio-ingénierie

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用于内皮靶向和药物传递的功能化10纳米高分子涂层金粒子的合成

Journal JoVE
Bio-ingénierie

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Journal JoVE Bio-ingénierie

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

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用于内皮靶向和药物传递的功能化10纳米高分子涂层金粒子的合成

DOI:

10.3791/56760-v

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10:38 min

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January 15, 2018

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Ming J. Cheng, Priya Prabakaran, Rajiv Kumar³, Srinivas Sridhar^2,3, Eno E. Ebong^4,5

¹Department of Chemical Engineering,Northeastern University, ²Nanomedicine Science and Technology Center,Northeastern University, ³Department of Physics,Northeastern University, ⁴Departments of Bioengineering,Northeastern University, ⁵Department of Neuroscience,Albert Einstein College of Medicine

Chapitres

00:05Titre
00:38Synthesis of Polyethylene Glycol-coated Gold Nanoparticles (PEG-AuNPs)
03:13Conjugation of Fluorophores onto the PEG-AuNP NH₂ Groups
04:56Characterization of Fluorescent PEG-AuNPs
08:46Results: Size and Biocompatibility of THPC-coated and Fluorescent PEG-AuNPs
10:19Conclusion

Summary

Traduction automatique

我们描述了一种合成具有生物相容性的10纳米金纳米粒子的方法, 其功能是在表面上涂上聚乙二醇。这些微粒可以使用在体外和在体内提供治疗的纳米细胞和细胞外空间, 难以获得常规纳米颗粒的大小。

Tags

Gold Nanoparticles Polymer Coating Functionalization Endothelium Targeting Drug Delivery Biocompatibility Fluorescence Imaging THPC Chloroauric Acid PEG Dialysis Lyophilization

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