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Radionukleid-fluorescens Reporter gen Imaging for at spore Tumor Progression i gnavere Tumor modeller
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Chapitres
- 00:04Titre
- 01:40Engineering and Characterization of Cancer Cells to Express the Radionuclide-fluorescence Fusion Reporter NIS-FP and [18F]BF4 - Synthesis
- 04:04In Vivo Imaging of NIS-FP Expressing Cells by nanoPET/CT
- 05:40Ex Vivo Analyses
- 06:33Results: Radiotracer Uptake in Cell Lines is Due to Specific NIS-FP Expression
- 08:24Conclusion
Vi beskriver en protokol for prækliniske i vivo sporing af kræft metastaser. Det er baseret på en radionukleid-fluorescens reporter kombinerer natrium Iodid symporter, opdaget af non-invasiv [18F] tetrafluoroborate-PET, og en fluorescerende proteiner for strømlinet ex vivo bekræftelse. Metoden er anvendelig for prækliniske i vivo celle tracking uden for tumor biology.
